Investigating the Causal Effect of Brain Expression of CCL2, NFKB1, MAPK14, TNFRSF1A, CXCL10 Genes on Multiple Sclerosis: A Two-Sample Mendelian Randomization Approach

Investigating the Causal Effect of Brain Expression of CCL2, NFKB1, MAPK14, TNFRSF1A, CXCL10 Genes on Multiple Sclerosis: A Two-Sample Mendelian Randomization Approach

Multiple Sclerosis (MS) exhibits considerable heterogeneity in phenotypic expression, course, prognosis and response to therapy. This suggests this disease involves multiple, as yet poorly understood, causal mechanisms. In this work we assessed the possible causal link between gene expression level...

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Bibliographic Details
Main Authors: Teresa Fazia, Andrea Nova, Davide Gentilini, Ashley Beecham, Marialuisa Piras, Valeria Saddi, Anna Ticca, Pierpaolo Bitti, Jacob L. McCauley, Carlo Berzuini, Luisa Bernardinelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Multiple Sclerosis
Mendelian randomization
gene expression
family data
NF-κB signaling pathway
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00397/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00397/full

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