Pathological Proteins Are Transported by Extracellular Vesicles of Sporadic Amyotrophic Lateral Sclerosis Patients

Pathological Proteins Are Transported by Extracellular Vesicles of Sporadic Amyotrophic Lateral Sclerosis Patients

Amyotrophic lateral sclerosis (ALS) is a progressive adult-onset neurodegenerative disease, that affects cortical, bulbar and spinal motor neurons, and it is considered a proteinopathy, in which pathological proteins (SOD1, TDP-43, and FUS) may accumulate and interfere with neuronal functions eventu...

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Bibliographic Details
Main Authors: Daisy Sproviero, Sabrina La Salvia, Marta Giannini, Valeria Crippa, Stella Gagliardi, Stefano Bernuzzi, Luca Diamanti, Mauro Ceroni, Orietta Pansarasa, Angelo Poletti, Cristina Cereda
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Neuroscience
Subjects:
amyotrophic lateral sclerosis
proteinopathy
extracellular vesicles
microvesicles
exosomes
SOD-1
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00487/full

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https://www.frontiersin.org/article/10.3389/fnins.2018.00487/full

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