p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway

p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway

p27Kip1 (p27) is a cyclin-CDK inhibitor and negative regulator of cell proliferation. p27 also controls other cellular processes including migration and cytoplasmic p27 can act as an oncogene. Furthermore, cytoplasmic p27 promotes invasion and metastasis, in part by promoting epithelial to mesenchym...

Full description

Bibliographic Details
Main Authors: Pauline Jeannot, Ada Nowosad, Renaud T Perchey, Caroline Callot, Evangeline Bennana, Takanori Katsube, Patrick Mayeux, François Guillonneau, Stéphane Manenti, Arnaud Besson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-03-01
Series:eLife
Subjects:
p27/Kip1
invadopodia
cortactin
PAK
invasion
Online Access:https://elifesciences.org/articles/22207

Internet

https://elifesciences.org/articles/22207

Similar Items