Jo-1 autoantigen-specific B cells are skewed towards distinct functional B cell subsets in anti-synthetase syndrome patients

Jo-1 autoantigen-specific B cells are skewed towards distinct functional B cell subsets in anti-synthetase syndrome patients

Abstract Background Anti-Jo-1 autoantibodies which recognize histidyl-tRNA synthetase identify patients with the rare rheumatologic disease, anti-histidyl-tRNA synthetase syndrome (Jo-1 ARS), a phenotypically distinct subset of idiopathic inflammatory myopathies (IIM). Jo-1-binding B cells (JBCs) ar...

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Bibliographic Details
Main Authors: Jennifer Young-Glazer, Alberto Cisneros, Erin M. Wilfong, Scott A. Smith, Leslie J. Crofford, Rachel H. Bonami
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Arthritis Research & Therapy
Subjects:
Autoimmune diseases
B lymphocytes
Autoimmunity
Myositis
Online Access:https://doi.org/10.1186/s13075-020-02412-8

Internet

https://doi.org/10.1186/s13075-020-02412-8

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