Robust Production of Merkel Cell Polyomavirus Oncogene Specific T Cells From Healthy Donors for Adoptive Transfer

Robust Production of Merkel Cell Polyomavirus Oncogene Specific T Cells From Healthy Donors for Adoptive Transfer

Virus positive Merkel cell carcinoma (VP-MCC) is an aggressive but immunogenic skin malignancy driven by Merkel cell polyomavirus (MCPyV) T antigen (TAg). Since adoptive T cell transfer (ACT) can be effective against virus-driven malignancies, we set out to develop a methodology for generating MCPyV...

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Bibliographic Details
Main Authors: Sarah I. Davies, John Barrett, Susan Wong, Mark Jesse Chang, Pawel J. Muranski, Isaac Brownell
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
CD4+ T-lymphocytes
skin neoplasms
immunotherapy
adoptive
translational medial research
cellular immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.592721/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.592721/full

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