High Adenosine Extracellular Levels Induce Glioblastoma Aggressive Traits Modulating the Mesenchymal Stromal Cell Secretome

High Adenosine Extracellular Levels Induce Glioblastoma Aggressive Traits Modulating the Mesenchymal Stromal Cell Secretome

Glioblastoma is an aggressive, fast-growing brain tumor influenced by the composition of the tumor microenvironment (TME) in which mesenchymal stromal cell (MSCs) play a pivotal role. Adenosine (ADO), a purinergic signal molecule, can reach up to high micromolar concentrations in TME. The activity o...

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Bibliographic Details
Main Authors: Deborah Pietrobono, Chiara Giacomelli, Laura Marchetti, Claudia Martini, Maria Letizia Trincavelli
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
glioblastoma
adenosine
tumor microenvironment
mesenchymal stromal cells
co-culture
Online Access:https://www.mdpi.com/1422-0067/21/20/7706

Internet

https://www.mdpi.com/1422-0067/21/20/7706

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