High Adenosine Extracellular Levels Induce Glioblastoma Aggressive Traits Modulating the Mesenchymal Stromal Cell Secretome
Glioblastoma is an aggressive, fast-growing brain tumor influenced by the composition of the tumor microenvironment (TME) in which mesenchymal stromal cell (MSCs) play a pivotal role. Adenosine (ADO), a purinergic signal molecule, can reach up to high micromolar concentrations in TME. The activity o...
Main Authors: | Deborah Pietrobono, Chiara Giacomelli, Laura Marchetti, Claudia Martini, Maria Letizia Trincavelli |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-10-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/21/20/7706 |
Similar Items
-
Adenosine Depletion as A New Strategy to Decrease Glioblastoma Stem-Like Cells Aggressiveness
by: Ignacio Niechi, et al.
Published: (2019-10-01) -
Decreased Equilibrative Nucleoside Transporter 1 (ENT1) Activity Contributes to the High Extracellular Adenosine Levels in Mesenchymal Glioblastoma Stem-Like Cells
by: Sebastián Alarcón, et al.
Published: (2020-08-01) -
Extracellular adenosine-mediated modulation of regulatory T cells
by: Akio eOhta, et al.
Published: (2014-07-01) -
Extracellular Vesicles in Glioblastoma Tumor Microenvironment
by: Anuroop Yekula, et al.
Published: (2020-01-01) -
The Expression of the Chemokine CXCL14 Correlates with Several Aggressive Aspects of Glioblastoma and Promotes Key Properties of Glioblastoma Cells
by: Barbara Fazi, et al.
Published: (2019-05-01)