Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Influences Sensitivity to Anti-IGF System Agents Through the Translational Regulation of IGF1R

Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Influences Sensitivity to Anti-IGF System Agents Through the Translational Regulation of IGF1R

Insulin-like growth factor 2 (IGF2) mRNA-binding protein 3 (IGF2BP3) is an oncofetal protein that binds RNA, thereby influencing the fate of target transcripts. IGF2BP3 is synthesized de novo in cancer, where it promotes proliferation, drug resistance, and metastasis via both IGF2-dependent and IGF2...

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Bibliographic Details
Main Authors: Caterina Mancarella, Michela Pasello, Maria Cristina Manara, Lisa Toracchio, Evelina Fiorenza Sciandra, Piero Picci, Katia Scotlandi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Endocrinology
Subjects:
insulin-like growth factor 2 mRNA-binding protein 3
IGF1R
anti-IGF agents
Ewing sarcoma
personalized treatment
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2018.00178/full

Internet

http://journal.frontiersin.org/article/10.3389/fendo.2018.00178/full

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