Immunosuppression after sepsis: systemic inflammation and sepsis induce a loss of naïve T-cells but no enduring cell-autonomous defects in T-cell function.

Immunosuppression after sepsis: systemic inflammation and sepsis induce a loss of naïve T-cells but no enduring cell-autonomous defects in T-cell function.

Sepsis describes the life-threatening systemic inflammatory response (SIRS) of an organism to an infection and is the leading cause of mortality on intensive care units (ICU) worldwide. An acute episode of sepsis is characterized by the extensive release of cytokines and other mediators resulting in...

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Bibliographic Details
Main Authors: Robby Markwart, Stephanie A Condotta, Robert P Requardt, Farina Borken, Katja Schubert, Cynthia Weigel, Michael Bauer, Thomas S Griffith, Martin Förster, Frank M Brunkhorst, Vladimir P Badovinac, Ignacio Rubio
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4277344?pdf=render

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http://europepmc.org/articles/PMC4277344?pdf=render

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