The impact of tumor nitric oxide production on VEGFA expression and tumor growth in a zebrafish rat glioma xenograft model.

To investigate the effect of nitric oxide on tumor development, we established a rat tumor xenograft model in zebrafish embryos. The injected tumor cells formed masses in which nitric oxide production could be detected by the use of the cell-permeant DAF-FM-DA (diaminofluorophore 4-amino-5-methylami...

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Bibliographic Details
Main Authors: Nadhir Yousfi, Benoist Pruvot, Tatiana Lopez, Lea Magadoux, Nathalie Franche, Laurent Pichon, Françoise Salvadori, Eric Solary, Carmen Garrido, Véronique Laurens, Johanna Chluba
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4359111?pdf=render