Deficiency of MecA in Streptococcus mutans Causes Major Defects in Cell Envelope Biogenesis, Cell Division, and Biofilm Formation

Deficiency of MecA in Streptococcus mutans Causes Major Defects in Cell Envelope Biogenesis, Cell Division, and Biofilm Formation

MecA is an adaptor protein that guides the ClpC/P-mediated proteolysis. A S. mutans MecA-deficient mutant was constructed by double-crossover allelic exchange and analyzed for the effects of such a deficiency on cell biology and biofilm formation. Unlike the wild-type, UA159, the mecA mutant, TW416,...

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Bibliographic Details
Main Authors: Arpan De, Ashton N. Jorgensen, Wandy L. Beatty, Jose Lemos, Zezhang T. Wen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Microbiology
Subjects:
Streptococcus mutans
MecA
stress tolerance response
biofilms
cell envelope biogenesis
Clp protease complex
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02130/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.02130/full

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