Tumor Arrests DN2 to DN3 Pro T Cell Transition and Promotes Its Conversion to Thymic Dendritic Cells by Reciprocally Regulating Notch1 and Ikaros Signaling

Tumor Arrests DN2 to DN3 Pro T Cell Transition and Promotes Its Conversion to Thymic Dendritic Cells by Reciprocally Regulating Notch1 and Ikaros Signaling

Tumor progression in the host leads to severe impairment of intrathymic T-cell differentiation/maturation, leading to the paralysis of cellular anti-tumor immunity. Such suppression manifests the erosion of CD4+CD8+ double-positive (DP) immature thymocytes and a gradual increase in CD4−CD8− double n...

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Bibliographic Details
Main Authors: Ipsita Guha, Avishek Bhuniya, Divanshu Shukla, Ashok Patidar, Partha Nandi, Akata Saha, Shayani Dasgupta, Nilanjan Ganguly, Sweta Ghosh, Arathi Nair, Subrata Majumdar, Bhaskar Saha, Walter J. Storkus, Rathindranath Baral, Anamika Bose
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
thymus
T cell
IL-10
DN2b
DC
Cancer
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00898/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00898/full

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