Deletion of a 4977-bp Fragment in the Mitochondrial Genome Is Associated with Mitochondrial Disease Severity.

Deletion of a 4977-bp Fragment in the Mitochondrial Genome Is Associated with Mitochondrial Disease Severity.

Large deletions in mitochondrial DNA (mtDNA) may be involved in the pathogenesis of mitochondrial disease. In this study, we investigated the relationship between a 4,977-bp deletion in the mitochondrial genome (ΔmtDNA(4977)) and the severity of clinical symptoms in patients with mitochondrial disea...

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Bibliographic Details
Main Authors: Yanchun Zhang, Yinan Ma, Dingfang Bu, Hui Liu, Changyu Xia, Ying Zhang, Sainan Zhu, Hong Pan, Pei Pei, Xuefei Zheng, Songtao Wang, Yufeng Xu, Yu Qi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4449107?pdf=render

Internet

http://europepmc.org/articles/PMC4449107?pdf=render

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