Deletion of a 4977-bp Fragment in the Mitochondrial Genome Is Associated with Mitochondrial Disease Severity.
Large deletions in mitochondrial DNA (mtDNA) may be involved in the pathogenesis of mitochondrial disease. In this study, we investigated the relationship between a 4,977-bp deletion in the mitochondrial genome (ΔmtDNA(4977)) and the severity of clinical symptoms in patients with mitochondrial disea...
Main Authors: | Yanchun Zhang, Yinan Ma, Dingfang Bu, Hui Liu, Changyu Xia, Ying Zhang, Sainan Zhu, Hong Pan, Pei Pei, Xuefei Zheng, Songtao Wang, Yufeng Xu, Yu Qi |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4449107?pdf=render |
Similar Items
-
Study of 4977-bp deletion of mitochondrial DNA induced mitochondrial dysfunction and apoptosis
by: Jing-yi Chen, et al.
Published: (2004) -
Analysis of the mitochondrial 4977 bp deletion in patients with hepatocellular carcinoma
by: Guo ZS, et al.
Published: (2017-06-01) -
Correlation of the 4977 bp mitochondrial DNA deletion with human sperm dysfunction
by: Rodakis George C, et al.
Published: (2009-02-01) -
Mitochondrial DNA 4977 bp Deletion in Chronic Cervicitis and Cervix Cancers
by: Kara M, et al.
Published: (2012-01-01) -
Mitochondrial DNA 4977 bp deletion is a common phenomenon in hair and increases with age
by: Yijie Zheng, et al.
Published: (2012-08-01)