GHGKHKNK Octapeptide (P-5m) Inhibits Metastasis of HCCLM3 Cell Lines via Regulation of MMP-2 Expression in in Vitro and in Vivo Studies

GHGKHKNK Octapeptide (P-5m) Inhibits Metastasis of HCCLM3 Cell Lines via Regulation of MMP-2 Expression in in Vitro and in Vivo Studies

P-5m, an octapeptide derived from domain 5 of HKa, was initially found to inhibit the invasion and migration of melanoma cells. The high metastatic potential of melanoma cells was prevented by the HGK motif in the P-5m peptide in vitro and in an experimental lung metastasis model, suggesting that P-...

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Bibliographic Details
Main Authors: Xun Zhu, Shuang Jiang, Bai-Rong Du, Pei-Ge Du, Peng Li, Wei-Guang Ding, Matsuura Hiroshi, Xiang-Feng Zhao, Dong-Mei Yan, Xiao Han
Format: Article
Language:English
Published: MDPI AG 2012-02-01
Series:Molecules
Subjects:
GHGKHKNK octapeptide
hepatocellular carcinoma
MMP-2
HCCLM3
cleaved high molecular weight kininogen
Online Access:http://www.mdpi.com/1420-3049/17/2/1357/

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http://www.mdpi.com/1420-3049/17/2/1357/

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