Repair-mediated duplication by capture of proximal chromosomal DNA has shaped vertebrate genome evolution.
DNA double-strand breaks (DSBs) are a common form of cellular damage that can lead to cell death if not repaired promptly. Experimental systems have shown that DSB repair in eukaryotic cells is often imperfect and may result in the insertion of extra chromosomal DNA or the duplication of existing DN...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-05-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC2671141?pdf=render |