Development, Validation, and Comparison of Two Mass Spectrometry Methods (LC-MS/HRMS and LC-MS/MS) for the Quantification of Rituximab in Human Plasma

Development, Validation, and Comparison of Two Mass Spectrometry Methods (LC-MS/HRMS and LC-MS/MS) for the Quantification of Rituximab in Human Plasma

Rituximab is a chimeric immunoglobulin G1-kappa (IgG1κ) antibody targeting the CD20 antigen on B-lymphocytes. Its applications are various, such as for the treatment of chronic lymphoid leukemia or non-Hodgkin’s lymphoma in oncology, and it can also be used in the treatment of certain autoimmune dis...

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Bibliographic Details
Main Authors: Aurélien Millet, Nihel Khoudour, Dorothée Lebert, Christelle Machon, Benjamin Terrier, Benoit Blanchet, Jérôme Guitton
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
Rituximab
quadripolar mass spectrometer
albumin depletion
pharmacokinetics
orbitrap mass spectrometer
IgG-immunocapture
Online Access:https://www.mdpi.com/1420-3049/26/5/1383

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https://www.mdpi.com/1420-3049/26/5/1383

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