HIV antiretroviral exposure in pregnancy induces detrimental placenta vascular changes that are rescued by progesterone supplementation

Abstract Adverse birth outcomes are common in HIV-positive pregnant women receiving combination antiretroviral therapy (cART), especially when cART is initiated in early pregnancy. The mechanisms remain poorly understood. Using a mouse model we demonstrate that protease inhibitor based-cART exposure...

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Bibliographic Details
Main Authors: Hakimeh Mohammadi, Eszter Papp, Lindsay Cahill, Monique Rennie, Nicole Banko, Lakmini Pinnaduwage, Janice Lee, Mark Kibschull, Caroline Dunk, John G. Sled, Lena Serghides
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-24680-w