Kinetic evaluation of photosensitivity in bi-stable variants of chimeric channelrhodopsins.

Channelrhodopsin-1 and 2 (ChR1 and ChR2) form cation channels that are gated by light through an unknown mechanism. We tested the DC-gate hypothesis that C167 and D195 are involved in the stabilization of the cation-permeable state of ChRWR/C1C2 which consists of TM1-5 of ChR1 and TM6-7 of ChR2 and...

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Bibliographic Details
Main Authors: Shoko Hososhima, Seiichiro Sakai, Toru Ishizuka, Hiromu Yawo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4366085?pdf=render