Genomic Aberrations in Crizotinib Resistant Lung Adenocarcinoma Samples Identified by Transcriptome Sequencing.

Genomic Aberrations in Crizotinib Resistant Lung Adenocarcinoma Samples Identified by Transcriptome Sequencing.

ALK-break positive non-small cell lung cancer (NSCLC) patients initially respond to crizotinib, but resistance occurs inevitably. In this study we aimed to identify fusion genes in crizotinib resistant tumor samples. Re-biopsies of three patients were subjected to paired-end RNA sequencing to identi...

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Bibliographic Details
Main Authors: Ali Saber, Anthonie J van der Wekken, Klaas Kok, M Martijn Terpstra, Lisette J Bosman, Mirjam F Mastik, Wim Timens, Ed Schuuring, T Jeroen N Hiltermann, Harry J M Groen, Anke van den Berg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4821611?pdf=render

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http://europepmc.org/articles/PMC4821611?pdf=render

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