HIV-1-Induced Small T Cell Syncytia Can Transfer Virus Particles to Target Cells through Transient Contacts

HIV-1-Induced Small T Cell Syncytia Can Transfer Virus Particles to Target Cells through Transient Contacts

HIV-1 Env mediates fusion of viral and target cell membranes, but it can also mediate fusion of infected (producer) and target cells, thus triggering the formation of multinucleated cells, so-called syncytia. Large, round, immobile syncytia are readily observable in cultures of HIV-1-infected T cell...

Full description

Bibliographic Details
Main Authors: Menelaos Symeonides, Thomas T. Murooka, Lauren N. Bellfy, Nathan H. Roy, Thorsten R. Mempel, Markus Thali
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Viruses
Subjects:
HIV
cell-cell fusion
syncytia
humanized mouse
3D culture
live cell imaging
Online Access:http://www.mdpi.com/1999-4915/7/12/2959

Internet

http://www.mdpi.com/1999-4915/7/12/2959

Similar Items