Control of Mesenchymal Stromal Cell Senescence by Tryptophan Metabolites

Control of Mesenchymal Stromal Cell Senescence by Tryptophan Metabolites

Cellular senescence contributes to aging and age-related disorders. High glucose (HG) induces mesenchymal stromal/stem cell (MSC) senescence, which hampers cell expansion and impairs MSC function. Intracellular HG triggers metabolic shift from aerobic glycolysis to oxidative phosphorylation, resulti...

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Bibliographic Details
Main Author: Kenneth K. Wu
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
type 2 diabetes
hyperglycemia
mesenchymal stromal/stem cells
5-methoxytryptophan
melatonin
cellular senescence mitochondrial dysfunction
Online Access:https://www.mdpi.com/1422-0067/22/2/697

Internet

https://www.mdpi.com/1422-0067/22/2/697

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