Extracellular Vesicles From Pathological Microenvironment Induce Endothelial Cell Transformation and Abnormal Angiogenesis via Modulation of TRPV4 Channels

Extracellular Vesicles From Pathological Microenvironment Induce Endothelial Cell Transformation and Abnormal Angiogenesis via Modulation of TRPV4 Channels

The soluble and mechanical microenvironment surrounding endothelial cells influences and instructs them to form new blood vessels. The cells in the pathological tumor microenvironment release extracellular vesicles (EVs) for paracrine signaling. EVs have been shown to induce angiogenesis by communic...

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Bibliographic Details
Main Authors: Brianna D. Guarino, Ravi K. Adapala, Anantha K. Kanugula, Nina M. Lenkey, Julie A. Dougherty, Sailaja Paruchuri, Mahmood Khan, Charles K. Thodeti
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
angiogenesis
endothelial cells
extracellular vesicles
tumor
TRPV4
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00344/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2019.00344/full

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