S-1-propenylcysteine improves TNF-α-induced vascular endothelial barrier dysfunction by suppressing the GEF-H1/RhoA/Rac pathway

S-1-propenylcysteine improves TNF-α-induced vascular endothelial barrier dysfunction by suppressing the GEF-H1/RhoA/Rac pathway

Abstract Background Vascular endothelial barrier function is maintained by cell-to-cell junctional proteins and contributes to vascular homeostasis. Various risk factors such as inflammation disrupt barrier function through down-regulation of these proteins and promote vascular diseases such as athe...

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Bibliographic Details
Main Authors: Kayo Kunimura, Satomi Miki, Miyuki Takashima, Jun-ichiro Suzuki
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Cell Communication and Signaling
Subjects:
Vascular endothelial barrier function
Adherens junction
Tight junction
Actin remodeling
S-1-propenylcysteine
Aged garlic extract
Online Access:https://doi.org/10.1186/s12964-020-00692-w

Internet

https://doi.org/10.1186/s12964-020-00692-w

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