First eight residues of apolipoprotein A-I mediate the C-terminus control of helical bundle unfolding and its lipidation.

First eight residues of apolipoprotein A-I mediate the C-terminus control of helical bundle unfolding and its lipidation.

The crystal structure of a C-terminal deletion of apolipoprotein A-I (apoA1) shows a large helical bundle structure in the amino half of the protein, from residues 8 to 115. Using site directed mutagenesis, guanidine or thermal denaturation, cell free liposome clearance, and cellular ABCA1-mediated...

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Bibliographic Details
Main Authors: Gregory Brubaker, Shuhui W Lorkowski, Kailash Gulshan, Stanley L Hazen, Valentin Gogonea, Jonathan D Smith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0221915

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https://doi.org/10.1371/journal.pone.0221915

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