Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB

Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB

Although important for early development, PU.1 is dispensable for mature B cell function, possibly owing to compensation by the related transcription factor SpiB. Here the authors show PU.1 and SpiB are collectively required for humoral immunity, through regulation of germinal centre formation and p...

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Bibliographic Details
Main Authors: Simon N. Willis, Julie Tellier, Yang Liao, Stephanie Trezise, Amanda Light, Kristy O’Donnell, Lee Ann Garrett-Sinha, Wei Shi, David M. Tarlinton, Stephen L. Nutt
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01605-1

Internet

https://doi.org/10.1038/s41467-017-01605-1

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