IL-6 Inhibition With MEDI5117 Decreases The Fraction of Head and Neck Cancer Stem Cells and Prevents Tumor Recurrence

IL-6 Inhibition With MEDI5117 Decreases The Fraction of Head and Neck Cancer Stem Cells and Prevents Tumor Recurrence

Head and neck squamous cell carcinomas (HNSCC) exhibit a small population of uniquely tumorigenic cancer stem cells (CSC) endowed with self-renewal and multipotency. We have recently shown that IL-6 enhances the survival and tumorigenic potential of head and neck cancer stem cells (i.e. ALDHhighCD44...

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Bibliographic Details
Main Authors: Kelsey A. Finkel, Kristy A. Warner, Samuel Kerk, Carol R. Bradford, Scott A. McLean, Mark E. Prince, Haihong Zhong, Elaine M. Hurt, Robert E. Hollingsworth, Max S. Wicha, David A. Tice, Jacques E. Nör
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558616300021

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http://www.sciencedirect.com/science/article/pii/S1476558616300021

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