Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS.
Human cyclophilin A, or CypA, encoded by the gene peptidyl prolyl isomerase A (PPIA), is incorporated into the HIV type 1 (HIV-1) virion and promotes HIV-1 infectivity by facilitating virus uncoating. We examined the effect of single nucleotide polymorphisms (SNPs) and haplotypes within the PPIA gen...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2007-06-01
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Series: | PLoS Pathogens |
Online Access: | https://doi.org/10.1371/journal.ppat.0030088 |