SPARC coordinates extracellular matrix remodeling and efficient recruitment to and migration of antigen-specific T cells in the brain following infection

SPARC coordinates extracellular matrix remodeling and efficient recruitment to and migration of antigen-specific T cells in the brain following infection

Abstract Central nervous system (CNS) injury and infection can result in profound tissue remodeling in the brain, the mechanism and purpose of which is poorly understood. Infection with the protozoan parasite Toxoplasma gondii causes chronic infection and inflammation in the brain parenchyma. Contro...

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Bibliographic Details
Main Authors: Kathryn E. McGovern, J. Philip Nance, Clément N. David, Reed E. S. Harrison, Shahani Noor, Danielle Worth, Tyler A. Landrith, Andre Obenaus, Monica J. Carson, Dimitrios Morikis, Emma H. Wilson
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83952-0

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https://doi.org/10.1038/s41598-021-83952-0

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