Cell-free chromatin particles released from dying host cells are global instigators of endotoxin sepsis in mice.

Cell-free chromatin particles released from dying host cells are global instigators of endotoxin sepsis in mice.

We have earlier reported that cell-free chromatin (cfCh) particles that are released from dying cells, or those that circulate blood, can readily enter into healthy cells, illegitimately integrate into their genomes and induce dsDNA breaks, apoptosis and intense activation of inflammatory cytokines....

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Bibliographic Details
Main Authors: Indraneel Mittra, Kavita Pal, Namrata Pancholi, Pritishkumar Tidke, Sophiya Siddiqui, Bhagyeshri Rane, Jenevieve D'souza, Alfina Shaikh, Saili Parab, Sushma Shinde, Vishal Jadhav, Soniya Shende, Gorantla V Raghuram
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0229017

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https://doi.org/10.1371/journal.pone.0229017

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