JAK/STAT-Dependent Chimeric Antigen Receptor (CAR) Expression: A Design Benefiting From a Dual AND/OR Gate Aiming to Increase Specificity, Reduce Tumor Escape and Affect Tumor Microenvironment

JAK/STAT-Dependent Chimeric Antigen Receptor (CAR) Expression: A Design Benefiting From a Dual AND/OR Gate Aiming to Increase Specificity, Reduce Tumor Escape and Affect Tumor Microenvironment

Recent advances in cancer immunotherapy have attracted great interest due to the natural capacity of the immune system to fight cancer. This field has been revolutionized by the advent of chimeric antigen receptor (CAR) T cell therapy that is utilizing an antigen recognition domain to redirect patie...

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Bibliographic Details
Main Authors: Javad Khanali, Mohammadreza Azangou-Khyavy, Melika Boroomand-Saboor, Mobina Ghasemi, Hassan Niknejad
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
cancer
adoptive immunotherapy
chimeric antigen receptors T cells
tumor escape and relapse
tumor microenvironment
cancer-associated fibroblasts
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.638639/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.638639/full

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