Selected HIV-1 Env trimeric formulations act as potent immunogens in a rabbit vaccination model.

Selected HIV-1 Env trimeric formulations act as potent immunogens in a rabbit vaccination model.

BACKGROUND: Ten to 30% of HIV-1 infected subjects develop broadly neutralizing antibodies (bNAbs) during chronic infection. We hypothesized that immunizing rabbits with viral envelope glycoproteins (Envs) from these patients may induce bNAbs, when formulated as a trimeric protein and in the presence...

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Main Authors: Leo Heyndrickx, Guillaume Stewart-Jones, Marianne Jansson, Hanneke Schuitemaker, Emma Bowles, Luigi Buonaguro, Berit Grevstad, Lasse Vinner, Katleen Vereecken, Joe Parker, Meghna Ramaswamy, Priscilla Biswas, Guido Vanham, Gabriella Scarlatti, Anders Fomsgaard, NGIN Consortium
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3759472?pdf=render

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http://europepmc.org/articles/PMC3759472?pdf=render

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