DNA as Tunable Adaptor for siRNA Polyplex Stabilization and Functionalization

DNA as Tunable Adaptor for siRNA Polyplex Stabilization and Functionalization

siRNA and microRNA are promising therapeutic agents, which are engaged in a natural mechanism called RNA interference that modulates gene expression posttranscriptionally. For intracellular delivery of such nucleic acid triggers, we use sequence-defined cationic polymers manufactured through solid p...

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Bibliographic Details
Main Authors: Philipp Heissig, Philipp M. Klein, Philipp Hadwiger, Ernst Wagner
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
DNA nanostructures
nucleic acid delivery
polyplex
RNA interference
siRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117300896

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http://www.sciencedirect.com/science/article/pii/S2162253117300896

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