Reduction of CFU-GM and circulating hematopoietic progenitors in a subgroup of children with chronic neutropenia associated with severe infections and delayed recovery.

Reduction of CFU-GM and circulating hematopoietic progenitors in a subgroup of children with chronic neutropenia associated with severe infections and delayed recovery.

Myelopoiesis was evaluated in 66 pediatric patients with chronic neutropenia who were positive for anti-neutrophil antibodies (median age at diagnosis: 11 months, median neutrophil count at diagnosis: 419/μl). Other causes of neutropenia were excluded. Bone marrow morphology, clonogenic tests and/or...

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Main Authors: Fabio Timeus, Nicoletta Crescenzio, Luiselda Foglia, Alessandra Doria, Maria Giuseppina Stillitano, Emanuela Garelli, Raffaela Mazzone, Laura Vivalda, Stefano Vallero, Ugo Ramenghi, Paola Saracco
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0213782

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https://doi.org/10.1371/journal.pone.0213782

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