Genetic polymorphism and natural selection in the C-terminal 42 kDa region of merozoite surface protein-1 (MSP-1) among Plasmodium knowlesi samples from Malaysia

Genetic polymorphism and natural selection in the C-terminal 42 kDa region of merozoite surface protein-1 (MSP-1) among Plasmodium knowlesi samples from Malaysia

Abstract Background The merozoite surface protein-1 (MSP-1) gene encodes for a leading malaria vaccine candidate antigen. However, its extensive polymorphic nature represents a major obstacle to the development of a protective vaccine. Previously, a pilot study was carried out to explore the sequenc...

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Bibliographic Details
Main Authors: Nan Jiun Yap, Indra Vythilingam, Boon Peng Hoh, Xiang Ting Goh, Azdayanti Muslim, Romano Ngui, Yamuna Rajoo, Seow Huey Choy, Timothy William, Tsin Wen Yeo, Yvonne Ai-Lian Lim
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Parasites & Vectors
Subjects:
Plasmodium knowlesi
Malaysia
Merozoite surface protein
Genetic polymorphism
Natural selection
Online Access:http://link.springer.com/article/10.1186/s13071-018-3234-5

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http://link.springer.com/article/10.1186/s13071-018-3234-5

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