The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing coronavirus disease 2019 pandemic. How SARS-CoV-2 regulates cellular responses to escape clearance by host cells is unknown. Autophagy is an intracellular lysosomal degradation pathway for the clearance of v...

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Bibliographic Details
Main Authors: Yabin Zhang, Hao Sun, Rongjuan Pei, Binli Mao, Zhenyu Zhao, Huihui Li, Yong Lin, Kefeng Lu
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-021-00268-z