Learning protein constitutive motifs from sequence data

Statistical analysis of evolutionary-related protein sequences provides information about their structure, function, and history. We show that Restricted Boltzmann Machines (RBM), designed to learn complex high-dimensional data and their statistical features, can efficiently model protein families f...

Full description

Bibliographic Details
Main Authors: Jérôme Tubiana, Simona Cocco, Rémi Monasson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-03-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/39397