DNA Aptamers Block the Receptor Binding Domain at the Spike Protein of SARS-CoV-2

DNA Aptamers Block the Receptor Binding Domain at the Spike Protein of SARS-CoV-2

DNA aptamers are versatile molecular species obtained by the folding of short single-stranded nucleotide sequences, with highly specific recognition capabilities against proteins. Here we test the ability of DNA aptamers to interact with the spike (S-)protein of the SARS-CoV-2 viral capsid. The S-pr...

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Bibliographic Details
Main Authors: Fabrizio Cleri, Marc F. Lensink , Ralf Blossey
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
DNA aptamers
SARS-CoV-2
spike protein
molecular dynamics
angiotensin converting enzyme-2
free energies
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.713003/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.713003/full

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