Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway

Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway

New therapeutic targets for oral squamous cell carcinoma (OSCC) are urgently needed. We conducted genome-wide CRISPR-Cas9 screens in 21 OSCC cell lines, primarily derived from Asians, to identify genetic vulnerabilities that can be explored as therapeutic targets. We identify known and novel fitness...

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Bibliographic Details
Main Authors: Annie Wai Yeeng Chai, Pei San Yee, Stacey Price, Shi Mun Yee, Hui Mei Lee, Vivian KH Tiong, Emanuel Gonçalves, Fiona M Behan, Jessica Bateson, James Gilbert, Aik Choon Tan, Ultan McDermott, Mathew J Garnett, Sok Ching Cheong
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
CRISPR screen
oral squamous cell carcinoma
Hippo pathway
fitness genes
therapeutic targets
Online Access:https://elifesciences.org/articles/57761

Internet

https://elifesciences.org/articles/57761

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