IRAK4 Deficiency in a Patient with Recurrent Pneumococcal Infections: Case Report and Review of the Literature

IRAK4 Deficiency in a Patient with Recurrent Pneumococcal Infections: Case Report and Review of the Literature

Primary immunodeficiencies are genetic defects of the innate or adaptive immune system, resulting in a propensity to infections. The innate immune system is the first line of defense against pathogens and is critical to recognize microbes and start the inflammatory cascade. Sensing of microbes occur...

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Bibliographic Details
Main Authors: Karina Gobin, Mary Hintermeyer, Bertrand Boisson, Maya Chrabieh, Pegah Ghandil, Anne Puel, Capucine Picard, Jean-Laurent Casanova, John Routes, James Verbsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Pediatrics
Subjects:
IRAK4 deficiency
MYd88 deficiency
toll-like receptors
NF-κB essential modulator
NF-κB
IκBα
Online Access:http://journal.frontiersin.org/article/10.3389/fped.2017.00083/full

Internet

http://journal.frontiersin.org/article/10.3389/fped.2017.00083/full

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