Ubiquitin-Proteasome Modulating Dolabellanes and Secosteroids from Soft Coral <i>Clavularia flava</i>

Ubiquitin-Proteasome Modulating Dolabellanes and Secosteroids from Soft Coral <i>Clavularia flava</i>

We performed a high-content screening (HCS) assay aiming to discover bioactive molecules with proteasome inhibitory activity. By structural elucidation, we identified six compounds purified from soft coral <i>Clavularia flava</i>, which potentiates proteasome inhibition. Chemical structu...

Full description

Bibliographic Details
Main Authors: Che-Yen Chiu, Xue-Hua Ling, Shang-Kwei Wang, Chang-Yih Duh
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Marine Drugs
Subjects:
proteasome inhibition
dolabellane
secosteroids
soft coral
Online Access:https://www.mdpi.com/1660-3397/18/1/39

Internet

https://www.mdpi.com/1660-3397/18/1/39

Similar Items