A single nucleotide polymorphism in the Plasmodium falciparum atg18 gene associates with artemisinin resistance and confers enhanced parasite survival under nutrient deprivation

A single nucleotide polymorphism in the Plasmodium falciparum atg18 gene associates with artemisinin resistance and confers enhanced parasite survival under nutrient deprivation

Abstract Background Artemisinin-resistant Plasmodium falciparum has been reported throughout the Greater Mekong subregion and threatens to disrupt current malaria control efforts worldwide. Polymorphisms in kelch13 have been associated with clinical and in vitro resistance phenotypes; however, sever...

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Bibliographic Details
Main Authors: Kimberly F. Breglio, Roberto Amato, Richard Eastman, Pharath Lim, Juliana M. Sa, Rajarshi Guha, Sundar Ganesan, David W. Dorward, Carleen Klumpp-Thomas, Crystal McKnight, Rick M. Fairhurst, David Roberts, Craig Thomas, Anna Katharina Simon
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Malaria Journal
Subjects:
Artemisinin resistance
Autophagy
Fitness
Drug resistance
atg18
Online Access:http://link.springer.com/article/10.1186/s12936-018-2532-x

Internet

http://link.springer.com/article/10.1186/s12936-018-2532-x

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