G-Protein-Coupled Estrogen Receptor (GPER)-Specific Agonist G1 Induces ER Stress Leading to Cell Death in MCF-7 Cells

G-Protein-Coupled Estrogen Receptor (GPER)-Specific Agonist G1 Induces ER Stress Leading to Cell Death in MCF-7 Cells

The G-protein-coupled estrogen receptor (GPER) mediates rapid non-genomic effects of estrogen. Although GPER is able to induce proliferation, it is down-regulated in breast, ovarian and colorectal cancer. During cancer progression, high expression levels of GPER are favorable for patients’...

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Bibliographic Details
Main Authors: Diep-Khanh Ho Vo, Roland Hartig, Sönke Weinert, Johannes Haybaeck, Norbert Nass
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Biomolecules
Subjects:
GPER
GPER-specific agonist G1
UPR signaling
Ca<sup>2+</sup> efflux
ER stress
JNK
CAMKII
breast cancer
Online Access:https://www.mdpi.com/2218-273X/9/9/503

Internet

https://www.mdpi.com/2218-273X/9/9/503

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