NOS2 is critical to the development of emphysema in Sftpd deficient mice but does not affect surfactant homeostasis.

NOS2 is critical to the development of emphysema in Sftpd deficient mice but does not affect surfactant homeostasis.

Surfactant protein D (SP-D) has important immuno-modulatory properties. The absence of SP-D results in an inducible NO synthase (iNOS, coded by NOS2 gene) related chronic inflammation, development of emphysema-like pathophysiology and alterations of surfactant homeostasis.In order to test the hypoth...

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Bibliographic Details
Main Authors: Lars Knudsen, Elena N Atochina-Vasserman, Chang-Jiang Guo, Pamela A Scott, Beat Haenni, Michael F Beers, Matthias Ochs, Andrew J Gow
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3897517?pdf=render

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http://europepmc.org/articles/PMC3897517?pdf=render

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