An Inhibitor of NF-κB and an Agonist of AMPK: Network Prediction and Multi-Omics Integration to Derive Signaling Pathways for Acteoside Against Alzheimer’s Disease

An Inhibitor of NF-κB and an Agonist of AMPK: Network Prediction and Multi-Omics Integration to Derive Signaling Pathways for Acteoside Against Alzheimer’s Disease

Alzheimer’s disease (AD) is the most frequent type of dementia. Acteoside (ACT) is a compound isolated from Cistanche tubulosa, which possesses excellent neuroprotective properties. However, the underlying mechanism of ACT in regulating microglia polarization remains ill-defined. Therefore, a comput...

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Bibliographic Details
Main Authors: Ying-Qi Li, Yi Chen, Si-Qi Jiang, Yuan-Yuan Shi, Xiao-Li Jiang, Shan-Shan Wu, Ping Zhou, Hui-Ying Wang, Ping Li, Fei Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
acteoside
BV-2 cells
metabolism
RNA-seq
mitochondria
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.652310/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.652310/full

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