Ablation of NG2 proteoglycan leads to deficits in brown fat function and to adult onset obesity.

Ablation of NG2 proteoglycan leads to deficits in brown fat function and to adult onset obesity.

Obesity is a major health problem worldwide. We are studying the causes and effects of obesity in C57Bl/6 mice following genetic ablation of NG2, a chondroitin sulfate proteoglycan widely expressed in progenitor cells and also in adipocytes. Although global NG2 ablation delays early postnatal adipog...

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Bibliographic Details
Main Authors: Yunchao Chang, Zhi-Gang She, Kenji Sakimura, Amanda Roberts, Karolina Kucharova, David H Rowitch, William B Stallcup
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3266271?pdf=render

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http://europepmc.org/articles/PMC3266271?pdf=render

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