A novel pentapeptide targeting integrin β3-subunit inhibits platelet aggregation and its application in rat for thrombosis prevention

A novel pentapeptide targeting integrin β3-subunit inhibits platelet aggregation and its application in rat for thrombosis prevention

Background: Antiplatelet therapy plays a pivotal role in the prevention and treatment of thrombotic diseases. We reported the screening of P1C as a novel integrin-binding peptide from the C-terminal of connective tissue growth factor. Primary study indicated that P1C has potential against platelet a...

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Bibliographic Details
Main Authors: Qingrong eQu, Naifeng eLiu, Guoqiu eWu, Xiaobo eFan, Yamin eLiu, Xuejiao eYan
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Pharmacology
Subjects:
Blood Coagulation
Integrin beta3
Thrombosis
Platelet
Keywords: peptides
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00049/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00049/full

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