Quantitative sequence-function relationships in proteins based on gene ontology

<p>Abstract</p> <p>Background</p> <p>The relationship between divergence of amino-acid sequence and divergence of function among homologous proteins is complex. The assumption that homologs share function – the basis of transfer of annotations in databases – must theref...

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Bibliographic Details
Main Authors: Lesk Arthur M, Altman Naomi, Blankenberg Daniel J, Sangar Vineet
Format: Article
Language:English
Published: BMC 2007-08-01
Series:BMC Bioinformatics
Online Access:http://www.biomedcentral.com/1471-2105/8/294