Polymicrobial Sepsis Impairs Antigen-Specific Memory CD4 T Cell-Mediated Immunity

Polymicrobial Sepsis Impairs Antigen-Specific Memory CD4 T Cell-Mediated Immunity

Patients who survive sepsis display prolonged immune dysfunction and heightened risk of secondary infection. CD4 T cells support a variety of cells required for protective immunity, and perturbations to the CD4 T cell compartment can decrease overall immune system fitness. Using the cecal ligation a...

Full description

Bibliographic Details
Main Authors: Frances V. Sjaastad, Tamara A. Kucaba, Thamotharampillai Dileepan, Whitney Swanson, Cody Dail, Javier Cabrera-Perez, Katherine A. Murphy, Vladimir P. Badovinac, Thomas S. Griffith
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
sepsis
immune suppression
CD4 T cells
memory
IFN-gamma
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01786/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01786/full

Similar Items