Indole bearing thiadiazole analogs: synthesis, β-glucuronidase inhibition and molecular docking study

Indole bearing thiadiazole analogs: synthesis, β-glucuronidase inhibition and molecular docking study

Abstract Background Indole based thiadiazole derivatives (1–22) have synthesized, characterized by NMR and HREI-MS and evaluated for β-Glucuronidase inhibition. All compounds showed outstanding β-glucuronidase activity with IC50 values ranging between 0.5 ± 0.08 to 38.9 ± 0.8 µM when compared with s...

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Bibliographic Details
Main Authors: Noor Barak Almandil, Muhammad Taha, Mohammed Gollapalli, Fazal Rahim, Mohamed Ibrahim, Ashik Mosaddik, El Hassane Anouar
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Chemistry
Subjects:
Synthesis
Indole
Thiadiazole
β-Glucuronidases
Molecular docking
SAR
Online Access:http://link.springer.com/article/10.1186/s13065-019-0522-x

Internet

http://link.springer.com/article/10.1186/s13065-019-0522-x

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